Pharmaco EEG

Neuroanalytics Solutions for Preclinical Drug Development and Clinical Trials

Applications > Pharmaco EEG

Cross-Species Pharmaco-EEG: Sensitive drug efficacy and safety endpoints

From preclinical animal models to clinical research studies, LucerumKey offers a comprehensive solution for all modalities of EEG research, featuring rapid curation, and EEG spectral and tomographic computing with integrated statistics.

Seamless integrations with CROs and vendors for preclinical and clinical trial EEG collections

Clinical Research

Lucerum has developed robust and streamlined methods for conducting fast qEEG analyses specifically designed for clinical trials and research. We assess the type and timecourse of drug or therapy effects using topographic (surface spectral maps), tomographic (3D) maps, comprehensive network connectivity changes critical for understanding network-level and neuroplastogen drug mechanisms. The precision and breadth of our qEEG clinical trial outcomes are unmatched in the industry.

Clinical Trial Optimization

Reducing Heterogeneity of Response in Clinical Trials to Improve Patient Selection

We developed qEEG and connectome-based ML methodology specifically to improve patient selection in clinical trials. By identifying responders early from a heterogeneous population, later phase recruiting can focus on the subpopulation that fully responds to the drug, therefore reducing failures.

Preclinical Pharmaco-EEG

Implanted telemetry analytics in rodents and large animals

  • State-of-the-art pharmaco-EEG solutions for drug development using spectral analytics, spatial topographic maps, tomography, sleep-qEEG and much more.
  • Pharmacodynamic models and AI/ML drug class investigations

Find out how we support preclinical telemetry data collections

Preclinical Tomography

Unique Non-Human Primate tomography models designed to align with toxicology studies

qEEG tomography is an advanced EEG analytical method that provides a three-dimensional precise localization of the source of electrical activity within the brain and a detailed view of network states.

Our advanced qEEG tomography monkey model is tailored for fast results supporting IND studies. By employing precise source localization methods, such as swLORETA, we create detailed three-dimensional statistical images of drug-induced changes in brain activity and network effects.

Preclinical Sleep-qEEG

By integrating qEEG with sleep analytics (sleep scoring), researchers gain a deeper understanding of the effects of drugs on both sleep architecture and underlying oscillatory brain activity, increasing the translational relevance of preclinical findings.

  • Combining qEEG with sleep scoring enables analysis of the time spent in each of the sleep stages (sleep scoring). In addition, quantifying changes in each EEG frequency across specific sleep stages increases the predictive value of EEG for drug efficacy and provides insights into the neural mechanisms underlying drug effects on sleep. Sleep - qEEG biomarkers identified in preclinical studies may serve as translational endpoints, helping to predict clinical efficacy.

  • Sleep spindles are a hallmark of non-REM sleep and play a fundamental role in memory consolidation. Sleep spindles have been linked to various aspects of cognitive function, including memory consolidation, learning, and executive function. Therefore, monitoring changes in sleep spindle activity in preclinical studies can provide insights into the cognitive effects of drugs targeting sleep or related neurochemical pathways.

Bespoke EEG analytics

Our team of EEG experts is equipped to handle a wide range of scientific paradigms. We understand that each research question is unique, and our partners trust us to deliver custom solutions with precision and scientific rigor.

Partner with Us for Smarter Drug Development

Whether you're in the early stages of preclinical research and planning rodent or large animal studies, or managing multi-site clinical trials, our qEEG platform is designed to support every phase of your drug development journey. Contact us today to learn how we can support your goals with leading-edge qEEG technology.